Pip-Tapentadol Powder

Pip-Tapentadol, chemically known as 3-(2-methyl-1-(piperidin-1-yl)pentan-3-yl)phenol (also referred to as PiPTapentadol or piperidine-substituted tapentadol analog), is a novel synthetic research compound structurally related to the established analgesic tapentadol. This analog replaces the dimethylamino moiety with a piperidine ring, yielding the molecular formula C₁₇H₂₇NO and positioning it within the class of centrally acting opioid-like molecules featuring a meta-hydroxyphenyl core attached to a substituted propyl chain.

Offered here as a high-purity, fine white to off-white crystalline powder, our Pip-Tapentadol is synthesized and supplied strictly for in vitro laboratory research, analytical reference standard purposes, forensic analysis, structure-activity relationship (SAR) studies of atypical opioids, and investigative neuropharmacological experiments exploring modifications to dual-mechanism analgesics (μ-opioid receptor agonism combined with potential monoamine reuptake modulation).

As a structural variant of tapentadol (3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol, CAS 175591-23-8), Pip-Tapentadol presents opportunities for researchers to examine how N-heterocyclic substitution influences binding affinity, selectivity, metabolic stability, or functional activity at opioid receptors and related neurotransmitter systems in controlled experimental models.