O-Desmethyltramadol (O-DSMT) Powder

O-Desmethyltramadol, commonly referred to as O-DSMT or desmetramadol, is the primary active metabolite of the synthetic opioid tramadol. It belongs to the phenylpropylamine class of compounds and is chemically known as 3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol, with the molecular formula C₁₅H₂₃NO₂ (CAS: 73986-53-5 for the freebase; 80456-81-1 for the hydrochloride salt) and a molar mass of 249.35 g/mol.

Supplied as a premium-grade, fine white to off-white crystalline powder of exceptional purity, our O-DSMT is strictly designated for in vitro laboratory research, analytical reference purposes, forensic toxicology studies, pharmacokinetic investigations, and structure-activity relationship (SAR) examinations of atypical opioids and tramadol metabolites.

O-DSMT is of significant interest in neuropharmacological research due to its potent μ-opioid receptor agonism—reportedly up to several hundred times greater affinity than the parent tramadol—combined with retained monoaminergic activity profiles inherited from its precursor. Researchers utilize it to explore central opioid mechanisms, receptor binding kinetics, metabolic pathways bypassing CYP2D6 activation, comparative analgesia models, and interactions within monoamine systems without the variable metabolism associated with tramadol itself.