Norco (Hydrocodone Bitartrate / Acetaminophen) Tablets
$180.00$150.00
Norco® is the well-known brand designation for a fixed-ratio combination of hydrocodone bitartrate (an opioid analgesic) and acetaminophen (a non-opioid analgesic and antipyretic), commonly available in strengths such as 5 mg/325 mg, 7.5 mg/325 mg, and 10 mg/325 mg per tablet (CAS for hydrocodone bitartrate: 143-71-5; CAS for acetaminophen: 103-90-2).
Hydrocodone, chemically described as 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one (dihydrocodeinone), is a semi-synthetic opioid derived from codeine, functioning as a full mu-opioid receptor agonist with additional activity at other opioid receptors at higher doses. Acetaminophen (paracetamol; 4'-hydroxyacetanilide, molecular formula C₈H₉NO₂) provides central analgesic effects through incompletely elucidated mechanisms, often involving COX inhibition and endocannabinoid pathway modulation.
The synergy between these components enables enhanced analgesia for moderate to moderately severe pain models in pharmacological research, with hydrocodone contributing potent opioid-mediated effects and acetaminophen augmenting efficacy while potentially allowing lower opioid dosing in comparative studies.
Supplied here as high-purity, pharmaceutical-grade tablets (or equivalent research-grade compressed forms), our Norco reference material is intended exclusively for in vitro laboratory use, analytical reference standard purposes, forensic toxicology, pharmacokinetic profiling, opioid receptor binding assays, structure-activity relationship (SAR) investigations of semi-synthetic opioids combined with non-opioid analgesics, and controlled experimental studies on combination analgesic mechanisms, metabolism, or hepatotoxicity thresholds.