Alprazolam Powder

Alprazolam, systematically named 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, is a potent synthetic triazolobenzodiazepine derivative (molecular formula C₁₇H₁₃ClN₄, CAS: 28981-97-7, molecular weight 308.77 g/mol). This fused triazolo-benzodiazepine scaffold features a characteristic chlorine substitution at position 8, a methyl group at position 1, and a phenyl ring at position 6, conferring distinct binding affinity and pharmacokinetic properties within the benzodiazepine class.

Supplied as a high-purity, fine white to off-white crystalline powder, our alprazolam is produced and tested exclusively for in vitro scientific research, analytical reference standard applications, forensic toxicology, receptor binding assays, structure-activity relationship (SAR) investigations of triazolobenzodiazepines, and neuropharmacological studies examining positive allosteric modulation of GABA_A receptors.

As a classical benzodiazepine-site ligand, alprazolam functions as a positive allosteric modulator (PAM) at the benzodiazepine recognition site on heteropentameric GABA_A receptors (primarily those incorporating α1, α2, α3, or α5 subunits paired with γ2). Research applications often focus on its enhancement of GABA-mediated chloride influx, subtype-selective modulation profiles, anxiolytic-like versus sedative-hypnotic activity differentiation, or comparative studies with other 1,4-benzodiazepines and triazolo analogs.

Critical Research Notice This material is intended solely for legitimate laboratory and analytical research purposes. It is not for human consumption, animal administration, medical use, recreational purposes, or any form of in vivo exposure. Purchasers are solely responsible for full compliance with all relevant national, regional, and international regulations governing benzodiazepines and research chemicals. Safe laboratory practices—including proper personal protective equipment, controlled storage under inert conditions, and appropriate waste disposal—are mandatory.

Available in limited quantities with nitrogen-purged, vacuum-sealed packaging to maintain chemical stability and analytical integrity. Batch-specific Certificates of Analysis (CoA), including HPLC purity (>98%), identity confirmation (NMR/IR), and residual solvent data, are provided upon request.